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大量临床观察已证明,灰黄霉素治疗各种皮肤霉菌病有相当高的效应。但是亦已知道其对各种霉菌病的效果是不同的。对小孢子菌病病人的疗程必需较长,而且常见到治疗失败的复发病例。有作者用每日剂量不足、疗程太短、头发生长缓慢、药物吸收和在角层中蓄积降低来解释。某些霉菌学家亦不排除皮肤霉菌对灰黄霉素扰药现象的发展。亦有用个别病人机体内药物分布特性、药物不完全地到达病原体来解释。本文报道5例同时服用灰黄霉素与巴比妥盐药物在药理学上产生不相容性而引起对灰黄霉素抗药的病例。5例均为头部小孢子菌病患者,1名女孩、4名男孩。年龄7～13岁。培养结果病原菌为狗小
A large number of clinical observations have proved that griseofulvin treatment of various skin fungal disease has a very high effect. However, it is also known that its effect on various mycotic diseases is different. The course of treatment of patients with microsporum disease longer, and common treatment failure recurrence. The authors explain this with daily under-dosage, short course of treatment, slow hair growth, drug absorption and reduced accumulation in the horn. Some mycologists also do not rule out the development of griseofulvin-mediated disturbances in skin molds. It is also useful to explain the distribution of the drug in individual patient’s body and the drug does not reach the pathogen completely. This article reports 5 cases of taking griseofulvin and barbiturate drugs pharmacological incompatibility caused by the case of griseofulvin resistance. 5 cases were patients with microsporum head, 1 girl and 4 boys. Age 7 to 13 years old. Incubation results for small dogs