铅对女性生殖系统的影响,近年来国内外研究的资料较多,本文仅将手头的资料作一个粗略的总结,以供参考。一、影响内分泌的调节功能 Weibe等用雌鼠作了两次实验,第一次于交配前用铅处理,测得产后21天子宫雌二醇受体亲和力显著增加,但其受体量无变化;于怀孕第7天用铅处理至150天,测得子代鼠子宫每毫克蛋白质的雌二醇受体大约减少35％(P<0.05):同时也测得亲代鼠铅处理35～150天组子宫雌二醇受体量显著减少,受体亲和力显著增加(P<0.01)。表明铅可改变青春期前和成鼠子宫雌二醇受体量和亲和力。第二次用铅处理妊娠前或妊娠及哺乳期的雌鼠至断奶 Lead on female reproductive system, in recent years, more information on domestic and foreign research, this paper will only hand information as a rough summary for reference. First, the regulation of endocrine function Weibe other female rats made two experiments, the first time before mating with lead treatment, measured postpartum 21 days uterine estradiol receptor affinity increased significantly, but its receptor did not change ; Lead treatment to 150 days on the 7th day of pregnancy, the estradiol receptor per milligram of protein in the offspring mice was reduced by about 35% (P <0.05): 35-150 days Uterine estradiol receptor was significantly decreased, receptor affinity was significantly increased (P <0.01). Indicating that lead can alter the amount and affinity of estradiol receptors in pre-adolescent and adult rat uterus. The second lead treatment of pre-pregnancy or pregnancy and lactating females to weaning