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目的:探讨乳腺癌亚临床肿瘤剂量分割优化的可靠方法。方法:选择2013年1月至2015年4月期间本院收治的60例乳腺癌亚临床期患者作为研究对象,随机分为对照组和观察组,各30例。两组患者均本院行乳腺癌根治术或改良根治术后治疗,术后两组患者常规行化疗治疗,随后对照组常规放射治疗,观察组采用短疗程放射治疗,观察两组患者局部区域复发、生存率、美容效果及不良反应情况。结果:随访1年,观察组和对照组死亡率和局部复发率均无显著差异p>0.05。在皮肤不良反应方面,两组无显著差异p>0.05。观察组血液学毒性反应率(13.33%)略高于对照组(10.00%),但无显著组间差异p>0.05。两组美容效果比较无显著差异p>0.05。结论:短疗程放射治疗应用于乳腺癌亚临床期保乳术后治疗效果较为可靠,与常规疗程效果相似,应推广使用该疗法。
Objective: To explore a reliable method for optimizing the dose segmentation of subclinical breast cancer. Methods: 60 patients with breast cancer from January 2013 to April 2015 were selected as the study subjects. They were randomly divided into control group and observation group, with 30 cases in each group. Both groups of patients underwent radical mastectomy or modified radical mastectomy. Patients in both groups were treated with chemotherapy routinely, followed by routine radiotherapy in the control group, and short-course radiation therapy in the observation group. Local recurrence was observed in both groups. , survival rate, cosmetic effects and adverse reactions. Results: At 1 year follow-up, there was no significant difference in mortality and local recurrence rate between the observation group and the control group (p>0.05). In terms of adverse skin reactions, there was no significant difference between the two groups p>0.05. The hematological toxicity response rate of the observation group (13.33%) was slightly higher than that of the control group (10.00%), but there was no significant difference between the groups p>0.05. There was no significant difference between the two groups in cosmetic effects (p>0.05). Conclusion: Short-course radiation therapy is more reliable in breast cancer after subclinical breast-conserving surgery. It is similar to conventional treatment and it should be popularized.