膜性肾病在成人原发性肾小球肾炎引起肾病综合症中约占25～30%,约有1/3～1/4发展为肾功衰竭,而以肾小球肾炎为原因的肾衰约占10%。其病因为免疫复合物沉积于肾小球基底膜上皮,提示免疫功能增强,这已经病理学证实。但有关抗原种类及免疫反应的详细过程尚未明确。根据上述病理表现,对肾病综合征多用类固醇治疗。根据免疫抑制机制,Ponticelli等报道,对膜性肾病所致的肾病综合征的治疗,在应用类固醇的同时,并用氮芥。1992年8月27日,他又报道了单纯用类固醇治疗和类固醇与氮芥合用治疗两法的比较。观察了92例病人,根据年龄、性别、肾功能、蛋白尿程度、高血压程度、确诊时间、肾小管损害程度、活检组织沉积物位置等。观察分为2组,单剂治疗组只用甲基强的松龙治疗6个月,复合治疗组用甲基强的松龙与 Membranous nephropathy in adult primary glomerulonephritis caused nephrotic syndrome accounts for about 25 to 30%, about 1/3 to 1/4 of renal failure, and glomerulonephritis due to renal failure About 10%. The etiology of immune complexes deposited on the glomerular basement membrane epithelium, suggesting an increase in immune function, which has been confirmed by pathology. However, the exact process of antigen type and immune response is not yet clear. According to the above pathological findings, steroid treatment of nephrotic syndrome. According to the immunosuppressive mechanism, Ponticelli et al reported that the treatment of nephrotic syndrome caused by membranous nephropathy, combined with steroid, must be used. On August 27, 1992, he reported a comparison of two treatments with steroids alone and with steroids and nitrogen mustards. 92 patients were observed, according to age, gender, renal function, proteinuria, hypertension, diagnosis of time, the extent of renal tubular damage, biopsy tissue deposition location. The observation was divided into two groups, single-agent treatment group only treated with methylprednisolone for 6 months, combined treatment group with methylprednisolone and