目的:对烯丙基氯的衍生物,是提供一个特比萘芬中间体的制备方法,提高反选择性和产率,并提高安全性和经济性,减少由于不使用丁基锂的低温反应的难度。组成的方法包括:叔丁基乙炔和丙烯醛与格氏试剂制备烯丙基醇中间体反应的步骤;和烯丙基醇中间体与三氯化磷反应(PCl3)在非极性溶剂制备结构式1的烯丙基氯衍生物。最好的格氏试剂是 OBJECTIVES: For derivatives of allyl chloride, a process for the preparation of terbinafine intermediates is provided, which increases the selectivity and yield of the reaction, increases safety and economy, and reduces the effects of low temperature reactions due to the non-use of butyl lithium Difficulty. The method comprises the following steps: reacting t-butyl acetylene and acrolein with Grignard reagent to prepare allyl alcohol intermediate; and reacting allyl alcohol intermediate with phosphorus trichloride (PCl3) in non-polar solvent to prepare structural formula 1 allyl chloride derivatives. The best Grignard reagent is