有机磷农药中毒(AOPP)是基层医院常见的急危重症,死亡率颇高。快速、彻底地清除毒物是抢救的主要原则和关键。传统清除毒物的方法包括洗胃、导泻等以排除消化道的毒物,仅对轻、中度中毒有效[1],对重度中毒疗效欠佳。我们采用血浆置换疗法(PE)用于重度急性有机磷中毒病人的救治, Organophosphorus pesticide poisoning (AOPP) is a common acute crisis in primary hospitals, with high mortality. Quick and thorough removal of poison is the main principle and the key to rescue. The traditional methods of removing poison include gastric lavage and catharsis to eliminate the poison of digestive tract, which is effective only for light and moderate poisoning [1], and has poor curative effect on severe poisoning. We use plasma exchange therapy (PE) for the treatment of patients with severe acute organophosphate poisoning,