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本文采用ＰＣＲＲＦＬＰ技术对抗磷脂抗体阳性（ＡＰＡ＋）ＳＬＥ患者ＨＬＡＤＲＢ１、ＤＱＡ１ 和ＤＱＢ１ 基因进行分型研究， 同时以上海地区汉族随机人群作对照， 发现这类病人的ＤＲＢ１＊ ０８０３ＤＱＡ１＊ ０１０３ＤＱＢ１ ＊０６０１ 单倍型频率显著增高（ Ｐ＜ ０－０１） 相对危险率为４－４５， 说明该疾病与此单倍型存在着很强的关联。
In this paper, PCRRFLP technology against phospholipid antibody-positive (APA +) SLE patients HLA DRB1, DQA1 and DQB1 gene typing at the same time to Shanghai random group of Han Chinese as a control and found that such patients DRB1 * 0803 DQA1 * 0103 DQB1 * 0601 haplotype frequency was significantly higher (P <0-01) relative risk of 4-45, indicating that the disease and the haplotype there is a strong correlation.