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目的 研究辛伐他汀5mg治疗高脂血症的疗效及安全性。方法 62例高脂血症患者,年龄59.7±15.6岁,每晚口服辛伐他汀5mg,治疗8周。治疗前后查血脂、肝肾功能。结果 8周后总胆固醇、低密度脂蛋白胆固醇、甘油三脂、脂蛋白(a)分别降低22.7％±13.1％(P<0.01)、25.3％±21.1％(P<0.01)、18.6％±8.5％(P<0.05)、22.3％±19.1％(P<0.05),高密度脂蛋白胆固醇升高10.1％±4.4％(P>0.05)。调脂治疗总有效率为67.7％。治疗期间无严重不良反应。结论 低剂量辛伐他汀能安全有效地降低高脂血症患者的血脂水平,每晚5mg可作为高脂血症的起始治疗剂量。
Objective To study the efficacy and safety of simvastatin 5 mg in the treatment of hyperlipidemia. Methods Sixty-two patients with hyperlipidemia were aged 59.7 ± 15.6 years and received simvastatin 5 mg per night for 8 weeks. Before and after treatment check blood lipids, liver and kidney function. Results After 8 weeks, total cholesterol, LDL cholesterol, triglyceride and lipoprotein (a) decreased by 22.7% ± 13.1%, 25.3% ± 21.1%, 18.6% ± 8.5 (P <0.05), 22.3% ± 19.1% (P <0.05), and high density lipoprotein cholesterol by 10.1% ± 4.4% (P> 0.05). The total effective rate of lipid-lowering treatment was 67.7%. No serious adverse reactions during treatment. Conclusion Low-dose simvastatin can safely and effectively reduce the blood lipid level in patients with hyperlipidemia, and 5mg night can be taken as the initial therapeutic dose of hyperlipidemia.