论文部分内容阅读
目的:探讨特发性胎儿生长受限(IFGR)胎盘组织中XIAP、Bax的表达及意义。方法:选取我院2010年7月～2011年4月剖宫产分娩的IFGR孕妇30例作为实验组,同期因社会因素剖宫产分娩的正常足月孕妇30例作为对照组。用免疫组化法检测胎盘组织XIAP、Bax的表达水平。结果:①XIAP在胎盘合体滋养细胞中的表达,实验组(114.562±5.167)低于对照组(144.430±7.311),差异有统计学意义(P<0.05)。②Bax在胎盘合体滋养细胞中的表达,实验组(146.513±10.611)高于对照组(113.673±9.631),差异有统计学意义(P<0.05);③实验组胎盘组织中XIAP与Bax的表达呈负相关(r=-0.761,P<0.05);对照组胎盘组织中XIAP与Bax的表达无相关性(r=0.034,P>0.05)。结论:胎盘组织中XIAP表达降低、Bax表达增加促使了胎盘滋养细胞的过度凋亡,可能是IFGR发病机制中的重要环节之一。
Objective: To investigate the expression and significance of XIAP and Bax in placenta of idiopathic fetal growth restriction (IFGR). Methods: Thirty cases of pregnant women with IFGR delivered by cesarean section in our hospital from July 2010 to April 2011 were selected as experimental group. Thirty cases of normal full-term pregnant women delivered by cesarean section due to social factors were selected as control group. The expression of XIAP and Bax in placenta was detected by immunohistochemistry. Results: ① The expression of XIAP in placental syncytiotrophoblast cells was lower in the experimental group (114.562 ± 5.167) than in the control group (144.430 ± 7.311), the difference was statistically significant (P <0.05). The expression of Bax in placental syncytiotrophoblasts was significantly higher in experimental group (146.513 ± 10.611) than that in control group (113.673 ± 9.631) (P <0.05); ③Expression of XIAP and Bax in placenta of experimental group was (R = -0.761, P <0.05). There was no correlation between the expression of XIAP and Bax in control group (r = 0.034, P> 0.05). CONCLUSION: The decrease of XIAP expression in placenta and the increase of Bax expression induce excessive apoptosis of placental trophoblast cells, which may be one of the important links in the pathogenesis of IFGR.