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本文分析168例临床Ⅰ、Ⅱ期子宫内膜癌的临床病理特点及细胞胞浆类固醇受体含量对预后的影响。受体测定用蔗糖密度梯度法和葡聚糖吸附炭末法,结合蛋白分别大于10fmol/mg 及15fmol/mg 为受体阳性。168例均测定了雌激素受体,105例同时又测定了孕酮受体。结果:雌激素受体与组织分化、细胞核分化和(组织学证明的)宫外转移有明显关系。癌肿高、中、低分化病例,受体阳性率分别为82%、72%和46%。癌细胞核1、2、3,4级病例,受体阳性率分别为79%、79%、55%和33%.组织学证明有宫外转移的病例,受体阳性率为37%,无转移病例为74%。
This article analyzes 168 cases of clinical stage Ⅰ, Ⅱ endometrial cancer clinicopathological features and cytosolic steroid receptor on prognosis. The receptor was determined by sucrose density gradient method and dextran adsorption charcoal method, the binding protein was greater than 10fmol / mg and 15fmol / mg receptor positive. 168 cases were measured estrogen receptor, 105 cases at the same time measured the progesterone receptor. RESULTS: Estrogen receptors were significantly associated with tissue differentiation, nuclear differentiation and (histologically proven) extrauterine metastasis. Cancer high, moderate and poorly differentiated cases, the positive rate of receptors were 82%, 72% and 46%. The positive rate of cancer cells in nucleus 1, 2, 3, and 4 were 79%, 79%, 55% and 33%, respectively. Histology proved that there were cases of extrauterine metastasis with a positive rate of 37% 74% of cases.