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目的 了解地氟醚在最低流量循环紧闭麻醉中药代动力学的临床表现。 方法 ５０例麻醉分级（ＡＳＡ） Ⅰ～Ⅱ级全麻下的择期手术病人。麻醉诱导采用咪唑安定、芬太尼、琥珀胆碱。气管插管后开始１０ ｍ ｉｎ 氧流量为４ Ｌ／ｍ ｉｎ，行间歇正压控制呼吸，地氟醚挥发罐浓度（ＦＤ）８％ 。此后关闭回路，氧流量０．２０～０．３５Ｌ／ｍ ｉｎ，地氟醚ＦＤ １０％ ～１２％ 。维持地氟醚的肺泡浓度（ＦＡ）在６％ ±０．１％ 。间断给予维库溴胺维持肌肉松弛。 结果 地氟醚ＦＡ 达６％ 和ＦＡ／ＦＩ（吸入浓度）达０．９，分别为４．９±０．８ ｍ ｉｎ 和１２．４±０．２ ｍ ｉｎ，并能维持在０．９０～０．９５。麻醉停止后，５．７±２．４ ｍ ｉｎ 恢复自主呼吸，拔管时间９．７±０．８ ｍ ｉｎ。麻醉中脉搏血氧饱和度均１００％ ，吸入氧浓度≥８０％ 。 结论 地氟醚的低组织溶解特性使其麻醉诱导和麻醉恢复快，麻醉调控性强。地氟醚的药代动力学特性使其能安全、有效地在最低流量循环紧闭麻醉中使用。
Objective To understand the pharmacokinetics of desflurane in closed loop anesthesia with minimum flux. Methods Fifty patients undergoing elective surgery under anesthesia classification (ASA) Ⅰ ~ Ⅱ general anesthesia. Induction of anesthesia with midazolam, fentanyl, succinylcholine. After intratracheal intubation 10 m in oxygen flow 4 L / m in intermittent positive pressure control respiration, desflurane volatile tank concentration (FD) 8%. After the closure of the circuit, oxygen flow 0.20 ~ 0.35L / m in, desflurane FD 10% ~ 12%. Maintenance of desflurane alveolar concentration (FA) at 6% ± 0.1%. Vecuronium was administered intermittently to maintain muscle relaxation. Results Desflurane FA up to 6% and FA / FI (inhalation concentration) reached 0.9, 4.9 ± 0.8 and 12.4 ± 0.2 m in, respectively, and remained at 0.90 ~ 0.95. After anesthesia was stopped, spontaneous respiration was resumed at 5.7 ± 2.4 m in and extubation time was 9.7 ± 0.8 m in. Anesthesia pulse oximetry 100%, inhaled oxygen concentration ≥ 80%. CONCLUSION: Desflurane’s low tissue lysis properties make anesthesia induction and anesthesia recovery fast, and strong anesthetic regulation. The pharmacokinetic properties of desflurane make it safe and effective for use in closed-loop anesthesia with minimum flow rates.