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胆管癌在我国的发病率为0.01%~0.46%,占恶性肿瘤总数的2%;好发于50~70岁,男女比例为2.8∶1。由于早期不易发现、容易侵袭周围组织器官和发生远处转移是手术切除率低、预后差的根本原因,其诊治水平至今未能取得突破性进展[1]。因而从肿瘤生物学的角度寻求更好的预防、治疗方法是目前的研究热点。
The incidence of cholangiocarcinoma in China is 0.01% ~ 0.46%, accounting for 2% of the total number of malignant tumors; occurs in 50 to 70 years old, male to female ratio of 2.8: 1. As the early is not easy to find, easy to invade the surrounding tissues and organs and distant metastasis is the low surgical resection rate, the root causes of poor prognosis, the diagnosis and treatment has so far failed to make a breakthrough [1]. Therefore, from the perspective of tumor biology to seek better prevention and treatment is the current research hotspot.