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目的检测稳定型心绞痛患者及不稳定型心绞痛患者外周血血清高敏C反应蛋白(hsCRP)、巨噬细胞移动抑制因子(MIF)、白介素10(IL-10)水平,了解其变化与患者临床分型之间的关系。方法共收入43例稳定型心绞痛患者和50例不稳定型心绞痛患者,同时收入40例健康志愿者作为对照组,以ELISA法检测其外周血血清中hsCRP、MIF、IL-10水平并进行统计分析。结果不稳定型心绞痛患者血清hsCRP水平(12.53±2.89)mg/L高于对照组(3.46±1.02)mg/L及稳定型心绞痛患者(4.51±0.98)mg/L,差异有统计学意义;不稳定型心绞痛患者MIF水平(30.94±5.85)μg/L高于对照组(8.31±1.38)μg/L及稳定型心绞痛患者(9.85±1.44)μg/L,差异有统计学意义;稳定型心绞痛患者及对照组hsCRP及MIF水平比较差异无统计学意义。不稳定型心绞痛患者及稳定型心绞痛患者血清IL-10水平分别为(19.44±2.11)ng/L和(20.19±2.04)ng/L,与对照组(14.89±2.49)ng/L比较差异有统计学意义。结论稳定型心绞痛与不稳定型心绞痛患者的血清炎症反应与抗炎反应生物标志物存在不同的表达情况,提示心绞痛患者体内炎症反应与抗炎反应平衡与患者病情进展之间存在一定的关系。
Objective To detect the levels of hsCRP, MIF and IL-10 in peripheral blood of patients with stable angina pectoris and unstable angina pectoris, The relationship between. Methods A total of 43 patients with stable angina pectoris and 50 patients with unstable angina pectoris were enrolled and 40 healthy volunteers were enrolled as control group. The levels of hsCRP, MIF and IL-10 in peripheral blood were detected by ELISA and analyzed statistically . Results The serum hsCRP levels in patients with unstable angina pectoris (12.53 ± 2.89) mg / L were significantly higher than those in patients with stable angina (3.46 ± 1.02 mg / L and 4.51 ± 0.98 mg / L, respectively) The level of MIF in patients with stable angina (30.94 ± 5.85) μg / L was higher than that in patients in control group (8.31 ± 1.38) μg / L and patients with stable angina (9.85 ± 1.44) μg / L, the difference was statistically significant. Patients with stable angina There was no significant difference in hsCRP and MIF between control group and control group. The levels of IL-10 in patients with unstable angina pectoris and patients with stable angina pectoris were (19.44 ± 2.11) ng / L and (20.19 ± 2.04) ng / L respectively, which were statistically different from those in control group (14.89 ± 2.49) ng / L Significance of learning. Conclusion Serum inflammatory response and anti-inflammatory biomarkers have different expression in patients with stable angina pectoris and unstable angina pectoris, suggesting that there is a relationship between the inflammatory response and anti-inflammatory response in patients with angina pectoris and the progression of the disease.