论文部分内容阅读
目的在对预防出生儿神经管缺陷(neural tube defects,NTDs)实施以叶酸作为有效干预的情况下,研究其仍然高发的影响因素。方法采用1∶1配比的病例对照研究方法,选取生育过NTDs患儿的210例产妇组成病例组,从同年、同地市、同医院生育健康儿的产妇中选取对照。针对上述研究对象收集母亲围孕期相关行为因素并进行分析。结果孕期被动吸烟(OR=11.203,P<0.001)、孕期服药(OR=10.137,P=0.039)、孕前配偶接触有害物质(OR=6.231,P=0.003)为NTDs的危险因素,计划怀孕(OR=0.265,P=0.008)、服用叶酸(OR=0.158,P<0.001)、孕期精神状态好(OR=0.434,P<0.001)为保护因素。结论被动吸烟、孕期服药、配偶在妻子孕前接触有害物质可使NTDs发生的危险性增加,而计划怀孕、服用叶酸以及孕期精神状态好可降低NTDs的发生率。
Objective To study the influential factors of prevention of neural tube defects (NTDs) in children with folic acid as an effective intervention. Methods A case-control study with a ratio of 1: 1 was used. A total of 210 maternal cases of NTDs were selected to make a case-control study. Women from the same year, same city and same hospital were selected as controls. For the above subjects to collect mothers during pregnancy-related behavioral factors and analysis. (OR = 10.137, P = 0.039), prenatal maternal exposure to harmful substances (OR = 6.231, P = 0.003) were risk factors for NTDs during pregnancy (OR = 11.203, = 0.265, P = 0.008). Folic acid (OR = 0.158, P <0.001) and good mental state during pregnancy (OR = 0.434, P <0.001) were protective factors. Conclusions Passive smoking and medication during pregnancy may increase the risk of NTDs in spouses when exposed to harmful substances in their wives before pregnancy. However, the planned pregnancy, taking folic acid and good mental state during pregnancy may reduce the incidence of NTDs.