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目的:依据已有文献系统评价喜炎平注射剂不良反应的相关因素等。方法:收集自2015年1月1日起至2016年11月30日间有关喜炎平注射剂不良反应的文献,并按照纳入排除标准进行筛选后对研究内容进行整理统计分析。结果:入选的97篇有83篇不良反应症状较轻,7篇出现严重不良反应,不良反应具体(典型)症状表现的有75篇,不良反应用药情况分析统计比较的有26篇;共涉及患者例数为4583例,不良反应发生率为2.75%(126例,轻微症状109例,严重症状15例),以少儿(发生率56.35%)及老年(发生率较23.02%)为主;主要症状为全身性损害(42.06%)、皮肤及其附件(18.25%)、呼吸系统(16.67%)、心血管系统(15.08%)等。结论:根据文献内容喜炎平注射剂在使用中会出现不同程度的不良反应,建议在临床使用中结合患者的具体情况合理规范使用,以降低不良反应发生率。
Objective: To evaluate the related factors of adverse reactions of Xiyanping injection based on the existing literature system. Methods: The literature about the adverse reactions of Xiyanping injection from January 1, 2015 to November 30, 2016 was collected and screened according to the exclusion criteria. The research contents were collected and statistically analyzed. Results: Of the 97 selected articles, 83 had fewer adverse reactions, 7 had serious adverse reactions, 75 had typical (typical) adverse reactions, and 26 had statistic analysis of adverse drug reactions. The number of cases was 4583, the incidence of adverse reactions was 2.75% (126 cases, 109 cases of mild symptoms and 15 cases of severe symptoms), with children (56.35%) and elderly (23.02%). The main symptoms (42.06%), skin and its appendages (18.25%), respiratory system (16.67%), cardiovascular system (15.08%) and so on. Conclusion: According to the literature, Xiyanping injection will have different degrees of adverse reactions in use, it is recommended to use in clinical practice in combination with the specific circumstances of patients reasonable use to reduce the incidence of adverse reactions.