白细胞介素(IL)-1β是巨噬细胞产生的IL—1常见的类型,它有多种生物学活性,其中成纤维细胞增生、免疫增强、刺激骨吸收等与牙周病病理有关。作者用抗人IL-1βN-末端片段(117—131)抗血清通过免疫荧光染色检测了6名牙周病患者和4名牙周健康者的牙周组织内的IL—1β。发现IL—1β阳性细胞在病变和正常组织均局限于基底层,但染色强烈的IL—1β Interleukin (IL) -1β is a common type of IL-1 produced by macrophages. It has a variety of biological activities. Among them, fibroblast proliferation, immune enhancement and bone resorption are related to the pathology of periodontal disease. The authors tested IL-1β in periodontal tissues of 6 periodontal disease patients and 4 periodontal healthy persons by immunofluorescence staining with anti-human IL-1β N-terminal fragment (117-131) antisera. IL-1β-positive cells were found to be confined to the basal layer in both diseased and normal tissues, but strongly stained IL-1β