新生儿缺氧缺血性脑病(HIE)是围产期缺氧窒息而导致的缺氧缺血性损害,出现一系列脑病表现,发病率及死亡率极高。我所自1993年2月～1998年9月应用脑活素胞二磷胆碱联合治疗HIE取得显著疗效,现报告如下。 1 材料和方法 1.1 病例选择:我们选择1989年2月～1998年9月我科缺氧缺血性脑病患儿符合以下条件有:①中度或重度病例,生后24小时内入院,住院10天以上,经过充分治疗临床症状消失,痊愈出院。②中度病例的临床诊断标准,除必须具备意识障碍、肌张力低下和原始反射减弱外,尚需有前囟紧张或膨隆、惊厥、凝视或对光反应迟钝三项中的一项。上述神经症状持续3天以上。③重症病儿临床诊断标准为昏迷、自发动作消失、原始反射消失、惊厥和前囟膨 Neonatal hypoxic-ischemic encephalopathy (HIE) is hypoxia-ischemic damage caused by perinatal asphyxia due to hypoxia, with a series of encephalopathy manifestations, with a high morbidity and mortality. I have from February 1993 to September 1998 application of brain activity of citicoline combined treatment of HIE achieved significant effect, are as follows. 1 Materials and Methods 1.1 Case Selection: We choose February 1989 to September 1998 in our department children with hypoxic ischemic encephalopathy meet the following conditions are: ① moderate or severe cases, admission within 24 hours after birth, hospital 10 Days or more, after full treatment of clinical symptoms disappeared, discharged. ② The clinical diagnosis of moderate cases, in addition to the need to have the disturbance of consciousness, hypotonia and reduced initial reflex, but also the anterior fontanelle tension or bulging, convulsions, staring or light reaction to one of the three. The above neurological symptoms persisted for more than 3 days. ③ critically ill children clinical diagnostic criteria for coma, spontaneous disappearance of the original reflection disappeared, convulsions and anterior fontanel