由于口服避孕药和阴道药环各有优缺点,因此如能保持二者的优点并尽量减少其缺点,则对增加甾体避孕药的有效性、安全性及可接受性将具有显著意义。甾体避孕药直接经阴道给药则是解决这个问题的一种可能途径。近年来人们已开始重视并进行了这方面的临床研究。有人认为这种避孕方式可在计划生育门诊作为首选的抗生育措施推广应用。一、阴道的吸收功能早在1918年David Macht发表了一篇经典论文《药物和毒物通过阴道被吸收》。此后,越来越多的物质被证明可通过阴道吸 Because of the advantages and disadvantages of oral contraceptives and vaginal drug-ring, maintaining the benefits of both and minimizing their disadvantages will have significant implications for increasing the effectiveness, safety and acceptability of steroid contraceptives. The direct transvaginal administration of steroidal contraceptives is a possible solution to this problem. In recent years, people have begun to attach importance to and carried out clinical research in this area. Some people think that this way of contraception in family planning clinics as the preferred anti-fertility measures to promote the application. First, the vaginal absorption function As early as 1918 David Macht published a classic article “drugs and toxins absorbed through the vagina.” Since then, more and more substances have been shown to be absorbed through the vagina