Both endothelial lipase gene(LIPG)584C>T (rs2000813)polymorphism and alcohol consumption modulate serum lipid levels.But their interactions on serum lipid profiles are not well known.The present study was undertaken to detect the interactions of LIPG 584C>T polymorphism and alcohol consumption on serum lipid levels.Genotyping of the LIPG 584C>T was performed in 763 nondrinkers and 520 drinkers aged 15-85.Interactions between the genotypes and alcohol consumption were assessed by using a cross-product term.The levels of serum total cholesterol(TC),triglyceride (TG),high-density lipoprotein cholesterol(HDL-C),apolipoprotein (Apo) AI,and the ratio of ApoAI to ApoB were higher in drinkers than in nondrinkers(P<0.01 for all).There was no significant difference in the genotypic and allelic frequencies between nondrinkers and drinkers.The levels of serum TC, HDL-C and ApoAI in nondrinkers were different among the three genotypes(P<.05-.01).The subjects with CT genotype had higher serum TC,HDL-C and ApoAI levels than the subjects with CC genotype.The levels of serum HDL-C and ApoAI in drinkers were different among the three genotypes (P<.001 and P<.05;respectively).The individuals with TT genotype had higher serum HDL-C and ApoAI levels than the individuals with CC and CT genotypes.The levels of TC in nondrinkers were correlated with LIPG 584C>T allele (P<.05),whereas the levels of TG and HDL-C were associated with LIPG 584C>T alleles(P<.05) and genotypes (P<.05);respectively.The present study suggests that the subjects with TT genotype benefited more from alcohol consumption than the subjects with CT and TT genotypes in increasing serum HDL-C and ApoAI levels. Both endothelial lipase gene (LIPG) 584C> T (rs2000813) polymorphism and alcohol consumption modulate serum lipid levels. But their interactions on serum lipid profiles are not well known. The present study was undertaken to detect the interactions of LIPG 584C> T polymorphism and Alcohol consumption on serum lipid levels. Genotyping of the LIPG 584C> T was performed in 763 nondrinkers and 520 drinkers aged 15-85. Interactions between the genotypes and alcohol consumption were assessed by using a cross-product term. The levels of serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), apolipoprotein (Apo) AI, and the ratio of ApoAI to ApoB were higher in drinkers than in nondrinkers no significant difference in the genotypic and allelic frequencies between nondrinkers and drinkers. the levels of serum TC, HDL-C and ApoAI in nondrinkers were different among the three genotypes (P <.05-.01). The subjects with CT genotype had higher serum TC, HDL -C and ApoAI levels than the subjects with CC genotype. These levels of serum HDL-C and ApoAI in drinkers were different among the three genotypes (P <.001 and P <.05; respectively). Individuals with TT genotype had higher serum HDL-C and ApoAI levels than individuals with CC and CT genotypes. The levels of TC in nondrinkers were correlated with LIPG 584C> T allele (P <.05), whereas the levels of TG and HDL-C were associated with LIPG 584C> T alleles (P <.05) and genotypes (P <.05); respectively.The present study suggests that the subjects with TT genotype benefited more from alcohol consumption than the subjects with CT and TT genotypes in increasing serum HDL-C and ApoAI levels.