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目的 探讨系统性红斑狼疮患者血清免疫球蛋白水平及其与病程和疾病活动性的关系。方法 应用速率免疫比浊法测定 67例系统性红斑狼疮患者及 5 3名正常人血清IgG、IgA、IgM水平。结果 系统性红斑狼疮患者血清IgM水平为 ( 1 2± 0 6) g/L ,明显低于对照组 ( 1 5± 0 3 )g/L(P <0 0 1) ,IgM水平与病程和疾病活动性均无相关性 (r =0 113 9,P >0 0 5 ;t=0 692 9,P >0 0 5 )。结论 选择性IgM降低显示了系统性红斑狼疮中免疫缺陷的存在 ,同时也提示了免疫缺陷或免疫缺陷病与系统性红斑狼疮的发病之间存在密切的相关性。
Objective To investigate the serum immunoglobulin levels in patients with systemic lupus erythematosus and its relationship with disease course and disease activity. Methods Serum IgG, IgA and IgM levels were measured in 67 patients with systemic lupus erythematosus and 53 normal controls by rate-immune turbidimetry. Results The level of serum IgM in patients with systemic lupus erythematosus was (12 ± 0.6) g / L, which was significantly lower than that in the control group (15 ± 0 3) g / L (P <0.01) There was no correlation between activity (r = 0 113 9, P 0 05; t 0 692 9, P 0 05). Conclusions Selective IgM reduction shows the existence of immunodeficiency in systemic lupus erythematosus and also suggests a close correlation between immunodeficiency or immunodeficiency disease and the onset of systemic lupus erythematosus.