本文主要对《中国医学文摘·内科学》1979～1990年收摘的文献进行概述。 1967年加拿大学者Macklm在美国哈佛大学成功地测定了末梢气道阻力。1968年Anthonisen首次证明了一些慢支患者,采用常规肺功能检查未能发现异常,但用区域性肺功能测定,却有明显的病理生理改变,认为这些改变是由小气道阻塞所引起。同年Hogg根据尸体解剖资料提出了小气道病变的概念,引起临床医生的重视。小气道指管口内径≤2mm的相当于第6级分支以下的细支气管,亦称末梢气 This article mainly summarizes the literature collected from “Medical Abstracts and Internal Medicine of China” from 1979 to 1990. In 1967, Canadian scholar Macklm successfully measured peripheral airway resistance at Harvard University in the United States. Anthonisen first demonstrated in 1968 that some patients with chronic bronchitis were unable to detect abnormalities by routine pulmonary function tests. However, with regional pulmonary function tests, there was a significant pathophysiological change that was caused by small airway obstruction. In the same year, Hogg proposed the concept of small airway lesion based on the autopsy data, which attracted the attention of clinicians. Small airway tube port diameter ≤ 2mm equivalent to the sixth branch below the bronchioles, also known as peripheral gas