内皮素I(ET-I)是一种具有很强血管收缩作用的活性肽,在肺内可被大量合成,引起肺血管和支气管收缩。作者测定了13例急性呼衰病人血中ET-I浓度.并探讨其与血液动力学及呼吸动力学的关系。 13例因各种病因导致急性呼吸衰竭病人,由于低氧血症(PaO_2/FiO_2<280)行气管插管及机械通气治疗。通过调整FiO_2及PEEP使12例病人PaO_2>10kPa Endothelin I (ET-I) is a potent vasoconstrictive active peptide that can be synthesized in large quantities in the lungs, causing pulmonary and bronchoconstriction. The authors measured the concentration of ET-1 in 13 patients with acute respiratory failure and explored its relationship with hemodynamics and respiratory dynamics. Thirteen patients with acute respiratory failure due to various causes were treated with tracheal intubation and mechanical ventilation due to hypoxemia (PaO 2 / FiO 2 <280). By adjusting FiO_2 and PEEP 12 patients PaO_2> 10kPa