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目的观察左氧氟沙星与抗结核化疗方案对复治涂阳肺结核的治疗效果。方法 78例复治涂阳肺结核患者,依据治疗方法不同分为对照组(42例)和观察组(36例)。对照组实施强化期(3HRZE/6HRE)化疗,观察组在对照组治疗基础上结合左氧氟沙星治疗,分析不同方法疗效。结果两组患者治疗2、3、5个月末痰菌转阴率以及不良反应情况比较差异无统计学意义(P>0.05),治疗8个月末两组痰菌转阴率、病灶吸收率比较差异有统计学意义(P<0.05)。结论左氧氟沙星联合抗结核化疗方案治疗复治涂阳肺结核疾病,疗效显著,且安全可靠,值得应用推广。
Objective To observe the therapeutic effect of levofloxacin and antituberculous chemotherapy on retreatment of smear positive pulmonary tuberculosis. Methods 78 cases of retreatment of smear positive pulmonary tuberculosis patients were divided into control group (n = 42) and observation group (n = 36) according to different treatment methods. The control group was given intensive chemotherapy (3HRZE / 6HRE). The observation group was treated with levofloxacin on the basis of the control group, and the curative effects of different methods were analyzed. Results There was no significant difference in the negative rates of sputum bacteria and adverse reactions between the two groups at the end of 2, 3, and 5 months (P> 0.05). The negative rates of sputum negative conversion rate and absorption rate of the lesions at the end of 8 months of treatment were significantly different There was statistical significance (P <0.05). Conclusion Levofloxacin combined with anti-tuberculosis chemotherapy regimen for the treatment of smear positive pulmonary tuberculosis, significant effect, and safe and reliable, it is worth to promote the application.