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干扰素是一种具有广谱抗病毒、抗肿瘤和免疫调节作用的细胞因子,并被广泛应用于临床治疗病毒性疾病和肿瘤等。近期研究表明,干扰素具有抗SARS冠状病毒的作用,因此相关研究对防治SARS具有重要意义。本文对干扰素的受体、信号传导途径、抗病毒蛋白以及抑制干扰素发挥抗病毒作用的因素进行了综述。
Interferon is a kind of broad-spectrum anti-virus, anti-tumor and immune regulatory cytokines, and is widely used in clinical treatment of viral diseases and tumors. Recent studies have shown that interferon has anti-SARS coronavirus effect, so the relevant research on the prevention and treatment of SARS is of great significance. This review summarizes the factors that affect the receptor of IFN, the signaling pathways, the antiviral proteins and the antiviral effects of interferon.