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[目的]探讨N-端脑钠肽前体(NT-proBNP)在慢性阻塞性肺疾病(COPD)合并心力衰竭中的价值。[方法]86例COPD患者分为单纯COPD组和COPD合并肺心病组,用电化学发光法测定血浆NT-ProBNP。[结果]COPD合并肺心病组NT-ProBNP水平明显高于单纯COPD组,且NT-ProBNP水平在轻、中、重度肺动脉高压组间差异有统计学意义(P﹤0.01);NT-ProBNP与肺动脉收缩压、主肺动脉宽度、右心室前壁厚度和右心室舒张末内径有良好的相关性。[结论]血浆NT-ProBNP浓度能较好地反映COPD患者右心室功能状态。
[Objective] To investigate the value of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with chronic obstructive pulmonary disease (COPD) complicated with heart failure. [Methods] Eighty-six patients with COPD were divided into simple COPD group and COPD combined with pulmonary heart disease group, and the plasma NT-ProBNP was measured by electrochemiluminescence. [Results] The NT-ProBNP level in patients with COPD complicated with pulmonary heart disease was significantly higher than that in patients with COPD alone. The NT-ProBNP level was significantly different between mild, moderate and severe pulmonary hypertension group (P <0.01) Systolic blood pressure, the width of the main pulmonary artery, right ventricular anterior wall thickness and right ventricular end-diastolic diameter have a good correlation. [Conclusion] The plasma concentration of NT-ProBNP can better reflect the right ventricular function in patients with COPD.