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目的 :观察愈疡宁浸膏对 3种胃溃疡模型动物的治疗保护作用 ,并初步探讨可能机制。方法 :将动物分成生理盐水对照组 (阴性对照 )、胃苏冲剂组 (阳性对照 )、愈疡宁小、中、大剂量组 5组。分别灌胃给药一段时间后 ,按照传统造模方法诱导胃溃疡形成 ,然后观察溃疡点数 ;测定胃酸量、胃酸酸度、胃蛋白酶含量 ,并与对照组比较分析。结果 :愈疡宁浸膏能抑制大鼠幽门结扎型胃溃疡、小鼠利血平型胃溃疡的形成 ;促进乙酸烧灼型胃溃疡的愈合 ;抑制胃液的分泌 ,降低胃液的酸度和胃蛋白酶含量。此外 ,该药对小鼠胃肠运动功能有很强的促进作用 ;能抑制冰醋酸引起小鼠扭体反应。结论 :愈疡宁浸膏对各型胃溃疡均有不同程度的防治作用。其作用机制可能与该药物能减少溃疡鼠胃液的分泌、促进溃疡鼠胃肠运动、减轻溃疡鼠的疼痛等作用有关。
Objective : To observe the therapeutic and protective effects of Yuyangning extract on three kinds of gastric ulcer model animals, and to explore the possible mechanism. Methods: Animals were divided into normal saline control group (negative control), Weisu Granules group (positive control), Yuyangning small, medium and high dose group. After intragastric administration for a period of time, gastric ulcer was induced according to traditional modeling methods, and then the number of ulcer points was observed; the amount of gastric acid, acidity of stomach acid, and pepsin content were measured and compared with the control group. RESULTS: Yuyangning extract could inhibit the pylorus-ligated gastric ulcer and the formation of reserpine-induced gastric ulcer in rats; promote the healing of acetic acid-burning gastric ulcer; inhibit the secretion of gastric juice and reduce the acidity and pepsin content of gastric juice. . In addition, the drug has a strong role in promoting gastrointestinal motility in mice; it can inhibit the writhing response of mice induced by glacial acetic acid. Conclusion : Yuyangning extract has various preventive and therapeutic effects on various gastric ulcers. Its mechanism of action may be related to the drug’s ability to reduce gastric juice secretion in ulcerative mice, to promote gastrointestinal motility in ulcerative rats, and to relieve pain in ulcer rats.