疟疾疫苗规划的目标是要研制出能预防疟原虫红内期感染和限制已感染者发病率的多期、多抗原疫苗。Stowers和Miller曾认为,在美洲猴攻击感染模型(NWMCM)中的效能试验数据将可提供选择用于人类试验的最佳候选疫苗的有效方法,因此可加速疫苗发展。本文作者不同意此观点,认为NWM-CM的可预测价值仍不确定,需要用明确的现场试验结果作为人体疟疾疫苗效能的最终评判。 疟疾红内期疫苗候选抗原分子起码需要 The goal of the malaria vaccine program is to develop a multi-phase, multi-antigen vaccine that will prevent the infection of the red bloodstream of Plasmodium and limit the incidence of those already infected. Stowers and Miller have argued that performance test data in the American Monkeys Attack Infection Model (NWMCM) will provide an effective way to select the best candidate vaccine for human trials and thus speed vaccine development. The authors disagree with this view and argue that the predictable value of NWM-CM remains uncertain and requires definitive field-test results as the final assessment of the efficacy of the human malaria vaccine. Malaria Red vaccine candidate antigen molecules are at least needed