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目的:了解类风湿关节炎(PA)患者血清血管内皮细胞生长因子(VEGF)与病情活动性的相关性。方法:采用免疫学ELISA方法检测了RA患者活动组(30例)、缓解组(30例)及正常对照组(30例)的血清 VEGF,并分析血清VEGF与 RA病情活动指标之间的关系。结果:活动组 RA患者血清 VEGF(183.399±55.572pg/ml)显著高于缓解组(84.391±8.378pg/ml)及正常对照组(82.032±7.54pg/ml)(P<0.01),活动组患者血清 VEGF浓度与 RA病情活动指标 CRP(r=0.711,P<0.001)及 Stoke指数(r=0.638,P<0.001)是显著正相关,与 RF(r=0.161,P<0.05)、ESR(r=0.128,P<0.05)、双足双手X 线狭窄侵蚀积分(r=-0.011,P>0.05;r=0.024,P>0.05)无相关性。结论:血清VEGF与 RA的病情活动有关,检测血清VEGF有助于 RA活动性判断。
Objective: To investigate the correlation between serum vascular endothelial growth factor (VEGF) and disease activity in patients with rheumatoid arthritis (PA). Methods: The serum levels of VEGF in active group (30 cases), remission group (30 cases) and normal control group (30 cases) were detected by immunological ELISA. The relationship between serum VEGF and the activity of RA was analyzed. Results: Serum VEGF (183.399 ± 55.572pg / ml) in active RA patients was significantly higher than that in remission patients (84.391 ± 8.378pg / ml) and normal controls (82.032 ± 7.54pg / ml) (P <0.01) Serum VEGF concentration was positively correlated with RA activity index CRP (r = 0.711, P <0.001) and Stoke index (r = 0.638, P <0.001) = 0.128, P <0.05). There was no correlation between edentulous hands and feet of both feet (r = -0.011, P> 0.05; r = 0.024, P> 0.05). Conclusion: Serum VEGF is related to the activity of RA, and the detection of serum VEGF contributes to the determination of RA activity.