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目的:探讨血清胱抑制素在肝硬化患者肾功能损害中的应用价值。方法:选择2010年到2012年到本院进行肾功能损伤治疗的100例患者,随机抽取其中的25例患者作为对照组,其余75例按照Child-Pugh的等级分为三组,每组25例,对四组患者的相应指标进行比较,包括血尿素氮、血清肌酐、24h肌酐清除率以及血清CysC。结果:经过比较可以看出,随着Child-Pugh等级的升高,患者的24h肌酐清除率下降,而血清肌酐以及血清CysC呈现上升的趋势,可见24h肌酐清除率与血清肌酐、血清CysC呈负相关。其中,血清CysC的相关系数较高。结论:在检查过程中,运用血清CysC可以更早地发现肝硬化患者肾功能的损害程度,所以,将血清CysC作为检测肝硬化患者肾功能损害程度的指标具有积极意义,可有效防治肝肾素综合征。
Objective: To investigate the clinical value of serum levels of serum albumin in patients with liver cirrhosis. Methods: A total of 100 patients randomly selected from our hospital for treatment of renal dysfunction from 2010 to 2012 were selected as the control group, and the remaining 75 cases were divided into three groups according to Child-Pugh’s grade, 25 cases in each group , The corresponding indicators of the four groups of patients were compared, including blood urea nitrogen, serum creatinine, creatinine clearance 24h and serum CysC. Results: Compared with the increase of Child-Pugh grade, the creatinine clearance rate decreased and serum creatinine and serum CysC showed an upward trend. The rate of creatinine clearance 24h and serum creatinine and serum CysC were negative Related. Among them, the correlation coefficient of serum CysC is higher. Conclusion: CysC can detect the damage of renal function in patients with liver cirrhosis earlier. Therefore, it is of great significance to detect serum CysC as a marker of renal dysfunction in cirrhotic patients, Syndrome.