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目的 探讨血管内皮生长因子在儿童实体肿瘤中表达的意义。方法 对２０ 例肾母细胞瘤和２５ 例神经母细胞瘤，１５ 例对照组标本进行血管内皮生长因子（ＶＥＧＦ）免疫组化分析。结果 ＶＥＧＦ在神经母细胞瘤中的表达阳性为１３ 例（１３／２５） ，在肾母细胞瘤中表达阳性为１２ 例（１２／２０） ，ＶＥＧＦ的表达与肿瘤的临床分期、病理类型无统计学意义，而与肿瘤的转移存在显著性差异（ Ｐ＜０．０５）。对照组阳性为２ 例（２／１５）。结论 ＶＥＧＦ的表达与肿瘤的转移存在密切联系，它作为临床综合评估肿瘤预后标准之一存在着重要意义
Objective To investigate the significance of vascular endothelial growth factor (VEGF) expression in childhood solid tumors. Methods Immunohistochemical analysis of vascular endothelial growth factor (VEGF) was performed on 20 cases of nephroblastoma and 25 cases of neuroblastoma and 15 cases of control group. Results The positive expression rate of VEGF in neuroblastoma was 13 cases (13/25), 12 cases (12/20) in nephroblastoma, the expression of VEGF was not correlated with the clinical stage and pathological type Significance, but with the transfer of tumor there was a significant difference (P <0.05). The control group was positive in 2 cases (2/15). Conclusion The expression of VEGF is closely related to the metastasis of tumor, which is of great significance as one of the criteria for clinical evaluation of prognosis