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过去十年,一类钙抑制剂用于治疗心绞痛、冠脉痉挛及室上性心动过速获得成功。这类化合物抑制跨越心肌及血管平滑肌细胞的钙内流通道,并可能干扰细胞內钠的释放,解除兴奋收缩耦联,引起平滑肌松弛。血液动力学效应包括:减低冠脉及外周血管阻力,减低心肌收缩力。还可影响心脏电传导系统。硝苯吡啶为可口服及舌下含服的钙抑制剂,其作用可概括如下:(1)降低左室收缩及舒张压,(2)降低平均动脉压,
Over the past decade, a class of calcium inhibitors have been used successfully in the treatment of angina, coronary spasm and supraventricular tachycardia. Such compounds inhibit the calcium influx pathway across myocardial and vascular smooth muscle cells and may interfere with the release of intracellular sodium, releasing the excitation-contraction coupling, causing smooth muscle relaxation. Hemodynamic effects include: reduce coronary and peripheral vascular resistance, reduce myocardial contractility. Can also affect the cardiac electrical conduction system. Nifedipine is a calcium inhibitor that can be taken orally and sublingually, and its effects can be summarized as follows: (1) to reduce left ventricular systolic and diastolic blood pressure, (2) to decrease mean arterial pressure,