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目的研究头孢曲松钠与复方氯化钠注射液、乳酸钠林格注射液配伍稳定性;并模拟体内头孢曲松钠血药峰浓度和静脉注射葡萄糖酸钙出现的钙离子瞬间高浓度,研究此种浓度下,配伍液的稳定性。方法采用HPLC法测定配伍液头孢曲松钠含量,同时观察室温下配伍液外观、pH值、不溶性微粒变化。结果头孢曲松钠与复方氯化钠注射液配伍后,0～2 h澄清,2 h后配伍液有肉眼可见的白色混浊,pH值升高,头孢曲松钠含量下降,不溶性微粒增加;与乳酸钠林格注射液配伍头孢曲松钠含量下降;模拟体内浓度进行配伍,外观无变化,头孢曲松钠含量稍有下降。结论头孢曲松钠与复方氯化钠注射液、乳酸钠林格注射液不能配伍应用。静脉点滴头孢曲松钠达血药峰浓度后,成人是否可以静推葡萄糖酸钙,还有待进一步探讨。
Objective To study the stability of compatibility between ceftriaxone sodium and compound sodium chloride injection and sodium lactate Ringer’s injection and to simulate the peak plasma concentration of ceftriaxone sodium and the instant calcium ion concentration in intravenous injection of calcium gluconate. Species concentration, compatibility of the stability of the liquid. Methods HPLC method was used to determine the content of ceftriaxone sodium in the compatibility solution. Meanwhile, the appearance, pH value and the changes of insoluble particles at room temperature were observed. Results The compatibility of ceftriaxone sodium and compound sodium chloride injection clarified after 0-2 h. After 2 h, the compatibility liquid had visible white turbidity, pH value increased, the content of ceftriaxone sodium decreased, and the insoluble particles increased. Sodium lactate Ringer’s injection compatibility ceftriaxone sodium content decreased; simulated in vivo concentration compatibility, no change in appearance, a slight decline in ceftriaxone sodium content. Conclusion Ceftriaxone sodium and sodium chloride injection, sodium lactate Ringer injection can not be compatible. Intravenous ceftriaxone sodium peak blood concentration, whether adults can push the calcium gluconate, remains to be further explored.