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目的 观察小剂量阿司匹林 (ASA)对老年缺血性脑血管病 (ICVD)患者血小板聚集功能的影响。 方法 以花生四烯酸、二磷酸腺苷、肾上腺素和胶原为诱导剂检测了老年ICVD患者服用ASA(4 0mg/d) 70例、未服ASA30例及健康对照组 5 0例的血小板最大聚集率 (MAR)。 结果 40mg/d的ASA组中花生四烯酸、胶原和肾上腺素诱导MAR的变异系数较大 ,且 70例中有 2 5例对花生四烯酸诱导的聚集无显著抑制。此 2 5例中随机选取 10例ASA增至 80mg/d后 ,有 8例达到了对花生四烯酸聚集的显著抑制 ,另 2例继续增至 10 0mg/d后才达到。 结论 在老年ICVD患者中 ,小剂量ASA作用的个体差异较大 ,临床ASA效果需要实验室评价并需个体化
Objective To observe the effect of low-dose aspirin (ASA) on platelet aggregation in elderly patients with ischemic cerebrovascular disease (ICVD). Methods Arachidonic acid, adenosine diphosphate, epinephrine and collagen were used as inducers to detect the maximal aggregation of platelets in 70 elderly patients with ASVD (40 mg / d), 30 without ASA and 50 healthy controls Rate (MAR). Results The coefficient of variation of MAR induced by arachidonic acid, collagen and epinephrine in 40 mg / d ASA group was large, and 25 of 70 cases showed no significant inhibition on arachidonic acid induced aggregation. In these 25 cases, 10 cases were randomly selected ASA to 80mg / d, 8 cases reached a significant inhibition of arachidonic acid aggregation, and the other two cases continued to increase to 10 0mg / d before reaching. CONCLUSIONS: Individuals with low-dose ASA have a greater variability in older ICVD patients, and clinical ASA effects require laboratory evaluation and individualization