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1958年Pincus首次用雌激素和孕激素联合作为口服避孕药(OC)。1960年才有产品问世。70年代人们强调了OC的副作用,但80年代对类固醇避孕药又重新加以肯定。新的低剂量OC是有效且非常安全的。当前有四个大规模的口服避孕药流行病学的研究组织:二个在英国、即英国皇家医学院医生研究组和牛津家庭计划联合研究组;二个在美国,即Kaiser常设研究组(Walnut Creek)和妇女健康研究组。他们作了大量调查工
1958 Pincus first combination of estrogen and progestin as oral contraceptives (OC). In 1960 only products come out. The side effects of OC were emphasized in the 1970s, but steroid contraceptives were reaffirmed in the 1980s. The new low-dose OC is effective and very safe. There are currently four large-scale oral contraceptive epidemiological research organizations: two in the UK, the Royal College of Physicians Research Group and the Oxford Family Planning Joint Study Group, and two in the United States, the Kaiser Standing Research Group (Walnut Creek) and Women’s Health Research Group. They made a lot of investigators