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冠心病患者发生严重急性冠状动脉事件约70%是由易损斑块(VP)所致。不稳定斑块的破裂是急性冠状动脉综合征(ACS)发生的核心机制,其较冠状动脉狭窄程度及病变范围更能反映冠心病患者发生急性心血管事件。现代影像学技术的进展,特别是血管内超声(IVUS)及光学相干断层成像(OCT)对识别和判断VP的形态学特征,包括斑块的形态、成分,甚至功能状态提供了快速、可靠的信息支持,在诊断和评价冠状动脉斑块方面,高分辨率的0CT检测水平已近似于组织学检测水平。该文就VP形态学检测技术的进展和认识作一简要综述。
Approximately 70% of patients with severe acute coronary events in coronary heart disease are caused by vulnerable plaque (VP). Unstable plaque rupture is the core mechanism of acute coronary syndrome (ACS), which can better reflect the occurrence of acute cardiovascular events in patients with coronary heart disease than the extent of coronary stenosis and lesion range. Advances in modern imaging techniques, particularly intravascular ultrasound (IVUS) and optical coherence tomography (OCT), have provided a fast and reliable means of identifying and judging VP morphological features, including the morphology, composition and even functional status of plaques Information support, in the diagnosis and evaluation of coronary plaque, high-resolution 0CT detection level has been similar to the level of histological examination. This article gives a brief overview of the progress and understanding of VP morphometric detection technology.