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目的：研究高钾饮食对血管损伤后内膜增生的抑制作用。方法：用新西兰白兔制成主动脉内皮损伤模型。实验动物分成3组：空白对照组（n=20）、对照组（n＝20）、治疗组（n=20，添加钾剂饲入：3％KCl100ml/天）。每组动物分两批于本后7天、30天处死，取腹主动脉下端作实验数据测定。结果：高钾饮食可有效升高血钾水平，治疗组服钾7天至术后30天血K+水平较空白组和对照组显著升高（P＜0.05或＜0．01）。血管条3H－TdR掺入量对照组较空白组明显升高（P＜0．05），治疗组较对照组明显下降（p＜0．05）。血管平滑肌钙含量术后7天治疗组和对照组均明显升高，尤以对照组为甚，30天后治疗组降到空白组水平，但对照组水平仍较高（P＜0．05）。新生内膜面积和内膜/中膜面积比治疗组明显低于对照组（术后7天P＜0．05，术后30天P＜0．05）。结论：高钾饮食对血管损伤后内膜增生具有明显抑制作用，提示高钾饮食对于防治球囊成形术后血管再狭窄的发生具有潜在临床应用前景。
Objective: To study the inhibitory effect of high-potassium diet on intimal hyperplasia after vascular injury. Methods: Aortic endothelial injury model was made in New Zealand white rabbits. The experimental animals were divided into 3 groups: blank control group (n = 20), control group (n = 20), treatment group (n = 20, added potassium feeding: 3% KCl100ml / day). Each group of animals in two batches after 7 days, 30 days were sacrificed, take the lower end of the abdominal aorta for experimental data determination. Results: High potassium diet could effectively increase serum potassium level. The blood K + levels in the treatment group from the 7th day to the 30th day were significantly higher than those in the blank group and the control group (P <0.05 or <0.01). 3H-TdR incorporation in vascular strips was significantly higher in the control group than in the blank group (P <0.05), and significantly decreased in the treatment group compared with the control group (p <0.05). The calcium content of vascular smooth muscle in the treated group and the control group were significantly increased 7 days after the operation, especially in the control group. After 30 days, the treatment group dropped to the blank group level, but the control group remained high (P <0.05). Neointimal area and intima / media area ratio in the treatment group were significantly lower than those in the control group (P <0.05 on the 7th day and P <0.05 on the 30th day after the operation). CONCLUSION: High potassium diet has significant inhibitory effect on intimal hyperplasia after vascular injury, suggesting that high potassium diet has potential clinical application prospects for the prevention and treatment of vascular restenosis after balloon angioplasty.