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为探讨血高密度脂蛋白胆固醇（HDL－C）、载脂蛋白（aPo）及脂蛋白（a）[LP（a）]在脑血管病（CVD）发病机理中的作用，对68例CVD患者和48例非脑血管病患者（对照组）外周血HDL－C、aPoA1、aPoB100及LP（a）的含量进行检测并做了对比研究。结果：发现LP（a）比HDL－C、aPoA1及aPoB100对CVD的判别更敏感。而且缺血性脑血管病（ICVD）的HDL－C、aPoA1及aPoA1／B100均比对照组呈显著降低（P＜0．05～001），LP（a）较对照组呈显著性增高（P＜0．01）；但脑出血（CH）的aPoA，及LP（a）均较对照组呈显著性降低（P＜0．001）。提示低水平的HDL－C或aPoA1／B100降低可能是发生ICVD的危险因素之一；高水平的LP（a）是缺血性脑卒中的独立危险因素。CH与ICVD的检测结果恰好相反。我们认为aPoA1／B100比值及LP（a）水平可作为预测CVD的二项很有用的指标。而后者似乎是判别缺血性还是出血性脑卒中最有意义的因素。
To investigate the role of high density lipoprotein cholesterol (HDL-C), apolipoprotein (aPo) and lipoprotein (a) [LP (a)] in the pathogenesis of cerebrovascular disease (CVD) And 48 cases of non-cerebrovascular disease patients (control group), the content of HDL-C, aPoA1, aPoB100 and LP (a) were detected and compared. Results: LP (a) was found to be more sensitive to CVD than HDL-C, aPoA1 and aPoB100. The levels of HDL-C, aPoA1 and aPoA1 / B100 in ICVD were significantly lower than those in control group (P <0.05 ~ 001), while LP (a) <0.01). However, aPoA and LP (a) in cerebral hemorrhage (CH) were significantly lower than those in control group (P <0.001). It is suggested that low level of HDL-C or aPoA1 / B100 decrease may be one of the risk factors of ICVD. High level of LP (a) is an independent risk factor for ischemic stroke. CH and ICVD test results on the contrary. We consider the aPoA1 / B100 ratio and LP (a) levels to be useful indicators of predicting CVD. The latter seems to be the most significant factor in discriminating between ischemic and hemorrhagic strokes.