钙拮抗剂与地高辛配伍用于心功能不全合并心率失常的治疗,越来越受到临床的重视。然而,许多实验表明,二者联合用药时,钙拮抗剂可改变地高辛的药化动力学过程,增加了用药的复杂性,应予以注意。目前在临床上常用的钙拮抗剂主要有:硝苯吡啶。异搏定和硫氮革酮,它们对地高辛药代动力学过程的影响各有不同,观分述如下: (一)异搏定与地高辛。异搏定能显著地降低地高辛的肾清除率及非肾清除率,因而使地 Calcium antagonist and digoxin compatibility for the treatment of heart failure with arrhythmia, more and more clinically valued. However, many experiments show that when the combination of the two drugs, calcium antagonists can change the digoxin pharmacokinetic process, increasing the complexity of the medication, it should be noted. Currently used in clinical calcium antagonists are: nifedipine. Verapamil and sulfinpyridone, which have different effects on digoxin pharmacokinetic processes, are summarized below: (a) Verapamil and digoxin. Verapamil can significantly reduce the digoxin digoxin renal clearance and non-renal clearance, thus making the ground