干燥综合征是以外分泌腺减少和分泌组织及细胞破坏为特征的慢性免疫性疾病。干燥综合征可引起肺间质改变,许多病人表现为限制性通气障碍及弥散障碍。相反,亦有引起阻塞性通气障碍的报告。但对干燥综合征的气道形态学研究甚少。本文对干燥综合征患者的气道上皮细胞、杯状细胞和支气管腺体进行了形态测量分析,并与支气管腔内粘液容积进行了对比。 Sjogren’s syndrome is a chronic immunological disorder characterized by a decrease in exocrine glands and secretion of tissue and cells. Sjogren’s syndrome can cause interstitial lung changes, many patients show restrictive ventilatory disorders and diffuse disorders. On the contrary, there are also reports of obstructive ventilatory disorders. However, little is known about the airway morphology of Sjogren’s syndrome. In this paper, the morphology of bronchial epithelial cells, goblet cells and bronchial glands of patients with Sjogren’s syndrome were measured and compared with that of bronchial mucus volume.