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从靶细胞分泌的信号分子(如神经营养素)可激活轴突末梢相应受体(如Trks)形成配体-受体混合物在细胞内吞作用下进入内体,这种胞内吞细胞器可从轴突逆行转运至胞体,具有信号转运功能的这种细胞器称为信号内体[1]。信号内体的假设是建立在轴突终端观察到NGF结合并激活TrkA受体形成信号蛋白复合物的现象[2]。伴随受体介导的内吞作用,NGF激活的TrkA信号复合物被分类至内体亚群形成信号内体。信号内体参与调节与分类细胞信号,并在轴浆逆
Signaling molecules secreted from target cells, such as neurotrophins, activate the corresponding receptors (such as Trks) at the terminals of axons to form ligand-receptor complexes that enter the endosome under endocytosis, Sudden retrograde transport to the soma, with signal transduction of this organelle called the signal endosome [1]. The signal endosome hypothesis is based on the observation that at the terminal axon, NGF binds and activates the TrkA receptor to form signaling protein complexes [2]. Along with receptor-mediated endocytosis, NGF-activated TrkA signaling complexes are classified into endosome subpopulations to form endosomes. Signal endosomes are involved in the regulation and classification of cellular signals and are inversely associated with axial pulp