在儿科及小外科局部应用局麻药透皮制剂是安全和有效的。其主要特点是起效快(30～45分钟),去除药膏后疗效可持续3小时以上。盐酸丁卡因配成2、4、6％水性凝胶,不含药的凝胶作对照。体外透皮试验用改良Franz扩散池FDC-400,温度维持37℃,同时600rpm搅拌。盐酸丁卡因含量用离子对反相HPLC测定,在2～53.4 μg/ml间,线性良好(r>0.998)。实验结果说明含药量越高,流量越大。2％制剂每小时最大流量是透过Silastic101.6μg/cm~2,最低流量每小时透过人或小 Topical application of local anesthetic transdermal formulations in pediatrics and small surgeries is safe and effective. Its main feature is rapid onset (30 to 45 minutes), the effect of removing ointment can last more than 3 hours. Tetracaine hydrochloride dubbed 2,4,6% aqueous gel, drug-free gel as a control. In vitro transdermal tests were performed using a modified Franz Diffuser FDC-400 maintained at 37 ° C while stirring at 600 rpm. Tetracaine hydrochloride content was determined by ion-pair reverse phase HPLC with a good linearity (r> 0.998) between 2 and 53.4 μg / ml. Experimental results show that the higher the drug content, the greater the flow. The maximum flow rate of 2% formulation per hour through Silastic101.6μg / cm ~ 2, the minimum flow through the hour or small or small