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目的:观察丹参注射液联合硫酸镁注射液治疗对早发型子痫前期患者血压、凝血功能及妊娠结局的改善作用。方法:选取64例早发型子痫前期患者为研究对象,按照随机数字表法分为观察组与对照组各32例。对照组给予硫酸镁注射液治疗,观察组在对照组用药基础上联合丹参注射液治疗。观察2组治疗前后的平均动脉血压(MAP)、收缩压(SBP)、舒张压(DBP)及凝血功能[凝血酶原时间(PT)、纤维蛋白原(Fib)、D-二聚体]的变化,比较2组的围产结局及不良反应情况。结果:治疗前,2组MAP、SBP、DBP比较,差异均无统计学意义(P>0.05)。治疗后,2组MAP、SBP、DBP均较治疗前下降(P<0.05);观察组的MAP、SBP、DBP均低于对照组(P<0.05)。治疗前,2组PT、Fib、D-二聚体水平比较,差异均无统计学意义(P>0.05)。治疗后,2组PT均较治疗前延长,Fib、D-二聚体水平均较治疗前下降(P<0.05);观察组的PT长于对照组(P<0.05),Fib、D-二聚体水平低于对照组(P<0.05)。观察组新生儿重度窒息发生率低于对照组(P<0.05),新生儿体质量高于对照组(P<0.05)。结论:丹参注射液联合硫酸镁注射液治疗早发型子痫前期,可有效改善患者的血压、凝血功能及围产结局。
Objective: To observe the effect of Danshen injection and magnesium sulfate injection on the improvement of blood pressure, blood coagulation and pregnancy outcome in patients with preeclampsia. Methods: Sixty-four patients with early-onset preeclampsia were divided into observation group and control group according to the random number table method. The control group was treated with magnesium sulfate injection. The observation group was treated with Salvia miltiorrhiza injection on the basis of the control group. The mean arterial blood pressure (MAP), systolic blood pressure (SBP), diastolic blood pressure (DBP), and coagulation function (PT, fibrinogen, D-dimer) Changes, compared two groups of perinatal outcomes and adverse reactions. Results: Before treatment, there were no significant differences in MAP, SBP and DBP between the two groups (P> 0.05). After treatment, the MAP, SBP and DBP in the two groups were significantly lower than those before treatment (P <0.05). The MAP, SBP and DBP in the observation group were lower than those in the control group (P <0.05). Before treatment, there was no significant difference in the levels of PT, Fib and D-dimer between the two groups (P> 0.05). After treatment, the PT of both groups was longer than that before treatment, and the levels of Fib and D-dimer were lower than those before treatment (P <0.05); the PT of the observation group was longer than that of the control group (P <0.05) The body level was lower than that of the control group (P <0.05). The incidence of neonatal severe asphyxia in the observation group was lower than that of the control group (P <0.05), and the body weight of neonates was higher than that of the control group (P <0.05). Conclusion: Salvia miltiorrhiza injection combined with magnesium sulfate injection treatment of preeclampsia can effectively improve the patient’s blood pressure, coagulation and perinatal outcomes.