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目的 随机性比较羟基喜树碱联合方案与顺铂联合方案治疗晚期大肠癌的近期疗效。方法 对50例晚期大肠癌随机分成两组,A组用HCPT 6mg/m~2 Ⅳ D1—5,5—FU 375mg/m~2 Ⅳ D1—5,CF 200mg/m~2;B组用DDP20mg/m~2 Ⅳ D1—5,5—FU 375mg/m~2 Ⅳ D1—5,CF200mg/m~2。共2—3周期。结果 A组总有效率达36％,完全缓解率为4％,部分缓解率为32％,B组总有效率达32％,完全缓解率为4％,部分缓解率为28％,不良反应主要是白细胞下降、恶心、呕吐、腹泻、口腔炎。结论 羟基喜树碱联合方案与顺铂联合方案治疗晚期大肠痛的近期疗效相同,但B组消化道反应较重。
Objective To compare the short-term curative effect of the combination of hydroxycamptothecin and cisplatin in the treatment of advanced colorectal cancer. Methods 50 cases of advanced colorectal cancer were randomly divided into two groups. Group A used HCPT 6 mg/m~2 IV D1—5,5—FU—375 mg/m~2 IV D1—5,CF 200 mg/m~2; Group B used DDP 20 mg. /m~2 IV D1—5,5—FU 375mg/m~2 IV D1—5, CF200mg/m~2. A total of 2-3 cycles. Results The total effective rate in Group A was 36%, the complete remission rate was 4%, the partial remission rate was 32%, the total effective rate in Group B was 32%, the complete remission rate was 4%, and the partial remission rate was 28%. It is a drop in white blood cells, nausea, vomiting, diarrhea, stomatitis. Conclusion The short-term efficacy of hydroxycamptothecin combined with cisplatin in the treatment of advanced colonic pain is the same, but the digestive tract reaction in group B is heavier.