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为调查研究抗结核药物的不良反应,对我院1980年1月至1992年5月住院的263例肺结核患者,根据联合化疗药物的不同联用组合,将其分为四组,观察肝脏的损害与血尿酸浓度的变化等不良反应的发生率,以加强该类药物不良反应的防治.1 资料与方法本文收集1980年1月至1992年5月间住院3个月以上的肺结核病例,全部患者在治疗前均作详细体检及肝功能检查,部分病人测定血尿酸浓度.治疗过程中,每月复查1次肝功能,若出现异常则每2周复查1次.服吡嗪酰胺者,停药后2个月复查血尿酸含量.
To investigate the adverse reactions of anti-TB drugs, 263 patients with tuberculosis who were hospitalized from January 1980 to May 1992 in our hospital were divided into four groups according to different combinations of combination chemotherapy drugs to observe the damage of the liver And changes in serum uric acid concentration and other adverse reactions in order to strengthen the prevention and treatment of adverse reactions of these drugs.Materials and methodsIn this paper, from January 1980 to May 1992 were hospitalized more than 3 months of tuberculosis cases, all patients Before treatment are detailed examination and liver function tests, some patients measured serum uric acid concentration during the treatment, once a month review of liver function, if there is abnormal every 2 weeks review 1. Taking pyrazinamide, withdrawal 2 months after the review of blood uric acid content.