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目的探讨风湿热心脏炎患儿血浆内皮素（ET）及降钙素基因相关肽（CGRP）的临床意义。方法用放射免疫法测定19例风湿热心脏炎患儿及21的健康儿童血浆ET及CGRP。结果患儿治疗前血浆ET升高而CGRP降低，心功能好转后分别回降及回升。心功能Ⅲ、Ⅳ级和心功能Ⅰ、Ⅱ级患儿及对照组儿童血浆ET逐渐降低，差异均有显著性；而CGRP却逐渐升高，但后两组的比较差异无显著。治疗前患儿ET与CGRP水平成直线负相关（γ=0．68，P＜0．01）。结论血浆ET及CGRP可作为风湿热心脏炎患儿心功能状态的监测指标。
Objective To investigate the clinical significance of plasma endothelin (ET) and calcitonin gene related peptide (CGRP) in children with rheumatic fever and heart disease. Methods The plasma levels of ET and CGRP in 19 children with rheumatic fever and 21 healthy children were determined by radioimmunoassay. Results Before treatment in children with elevated plasma ET and CGRP decreased, cardiac function improved after the fall and rise. The levels of ET in children with cardiac function Ⅲ, Ⅳ and heart function Ⅰ, Ⅱ grade and control group decreased gradually, the difference was significant; while CGRP was gradually increased, but there was no significant difference in the latter two groups. Before treatment, ET and CGRP levels had a linear negative correlation (γ = 0.68, P <0.01). Conclusions Plasma ET and CGRP can be used as indicators of cardiac function in children with rheumatic fever and carditis.