变态反应是机体受到抗原物质刺激后引起的组织损伤和生理功能的紊乱,是异常的病理性的免疫反应。变态反应可分为四型,过敏反应是变态反应中的第Ⅰ型,即速发型超敏反应。近半个世纪来,由于医药卫生事业的发展,人们用药的机会大大增多,由药物引起的过敏反应亦越来越频繁。以往用以检测药物是否有过敏原性的常用方法是药典规定的方法,即用被试药先致敏豚鼠,然后再用原药进行攻击,观察过敏反应发生的症状如喷嚏、抓鼻、呼吸困难、抽搐昏倒或死亡。本文就有关过敏反应发生机理方面作进一步的探讨。一般认为过敏反应的发生是由于过敏原刺激机体产生免疫球蛋白IgE,这种IgE抗体钉附于肥大细胞及嗜硷 Allergy is the body caused by antigen-induced tissue damage and physiological disorders, is an abnormal pathological immune response. Allergy can be divided into four types, anaphylaxis allergy is the first type of allergy, the rapid-onset hypersensitivity. Nearly half a century, due to the development of medical and health services, people greatly increased the chance of medication, allergic reactions caused by the drug is also more and more frequent. In the past to detect whether the drug has allergenicity is a common method is prescribed by the Pharmacopoeia, that is, with the first test drug sensitized guinea pigs, and then use the original drug attack, observe the symptoms of allergic reactions such as sneezing, nose, breathing Difficult, convulsive fainting or death. This article on the mechanism of allergic reaction for further discussion. Is generally believed that the occurrence of allergic reactions is due to the allergen to stimulate the body to produce immunoglobulin IgE, IgE antibody nail attached to mast cells and alkalophilic