Alzheimer病(AD)是老年人最常见的痴呆类型,为一种神经变性疾病。传统观点认为,AD和血管性痴呆不论在发病机制和还是治疗上都是两种完全不同的痴呆类型,但是近年来越来越多的证据显示血管因素在AD的发生、发展中起着重要作用。文章对脑缺血及其危险因素,包括高血压、糖尿病、胆固醇等在AD的发生和发展中的作用做了综述,以期为预防和延迟AD的发生和进展提供新的策略。 Alzheimer’s disease (AD) is the most common form of dementia in the elderly and is a neurodegenerative disorder. The traditional view that AD and vascular dementia both in the pathogenesis and treatment are two different types of dementia, but in recent years, more and more evidence that vascular factors play an important role in the occurrence and development of AD . The article reviews the role of cerebral ischemia and its risk factors, including hypertension, diabetes, cholesterol in the occurrence and development of AD, in order to provide a new strategy for preventing and delaying the occurrence and progression of AD.