目的 骨癌痛是临床最常见的癌症疼痛之一,因缺乏模拟骨癌痛临床发病病理特征的药物研发体内模型,从而不能精准干预其发病过程、优化诊疗策略和药物.癌痛发生与神经科学、肿瘤学、免疫学和骨生物学均密切相关,通过积极借鉴融合现代医学和生物学发展的最新成果,对骨癌痛动物模型的优化和新建进行探索.提出“伏毒蚀骨扰神”为其发病的核心病机,针对核心病机则提出“补肾强骨、清透伏毒、安神止痛”的原则,除了传统的止痛药物,同时需要联用清透伏毒和安神药物,丰富祖国医学的疼痛发病理论.“,”Bone cancer pain is one of the most common cancer pain,the current effect remains to be improved.Lack of drug development in vivo model by simulation of bone cancer pain clinical pathogenesis,which can not accurately intervene in the pathogenesis of optimal diagnosis and treatment strategies and drugs is the main reason.Cancer pain is associated with neuroscience,oncology,immunology and bone biology,through the positive reference to the integration of modern medical and biological development of the latest results,put forward the “hidden toxin erosive bone and disturb spirit” for the pathogenesis of bone cancer pain,aim to the pathogenesis of the disease,put forward “strong kidney and bone,clear hidden toxin,stable spirit and soothe the relieve pain” principle.In addition to the traditional analgesic drugs,at the same time need to use clear hidden toxin and stable spirit drugs,enrich the theory of pain onset of the motherland medicine,and to explore the optimization and new construction of bone cancer pain animal model.