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本文对61名脑血栓形成患者、21名患者配偶及42名患者一级亲属的血清载脂蛋白 AI和 B 水平作了分析。结果发现患者血清载脂蛋白 AI 水平显著低于对照组(P<0.05):载脂蛋白 B 与 AI 比值极显著高于对照组(P<0.001)。患者一级亲属组血清较脂蛋白 AI 和 B 水平与对照组无明显差别,但载脂蛋白 B 与 AI 比值极显著高于对照组(P<0.001)。患者配偶线各项指标与对照组相比未发现显著差别。上述结果提示脑血栓形成的发生与低血清载脂蛋白 AI 水平及高载脂蛋白 B 与 AI 比值有关,患者及其一级亲属组低血清载脂蛋白 AI 水平及高载脂蛋白 B 与 AI 比值可能与遗传因素有关。
In this paper, serum apolipoprotein AI and B levels in 61 patients with cerebral thrombosis, 21 patients with spouses and 42 first-degree relatives were analyzed. The results showed that serum apolipoprotein AI levels were significantly lower than those of the control group (P <0.05). The ratio of apolipoprotein B to AI was significantly higher than that of the control group (P <0.001). Serum levels of serum lipoproteins in patients with first-degree relatives were not significantly different from those in control subjects, but the ratio of apolipoprotein B to AI was significantly higher than that of controls (P <0.001). Patient’s spouse line of the indicators compared with the control group found no significant difference. These results suggest that the occurrence of cerebral thrombosis with low serum apolipoprotein AI levels and high apolipoprotein B and AI ratio of patients and their first-degree relatives of low serum apolipoprotein AI levels and high apolipoprotein B and AI ratio May be related to genetic factors.