给大鼠ｉｇ维生素Ｅ１５０ｍｇ·ｋｇ－１·ｄ－１，３０ｍｉｎ后ｉｐ氯丁二烯（ＣＢＤ）８０ｍｇ·ｋｇ－１·ｄ－１，持续３ｗｋ，能明显防止由单独ｉｐＣＢＤ而引起的肝细胞色素Ｐ４５０，氨基比林脱甲基酶活性的降低及肝内脂质过氧化产物丙二醛含量升高；还可使线粒休与微粒体α－生育酚含量大幅度升高，并使肝受损指标血清甘胆酸含量下降，病理所见肝细胞变性坏死亦明显减轻。离休肝细胞以ＣＢＤ染毒发现，胞内游离钙浓度明显升高，并有明显的剂量依赖关系。 Rats were given ig vitamin E50 at 50 mg · kg-1 · d-1 for 30 min, and ip bolidine (CBD) 80 mg · kg-1 · d-1 for 3 weeks, which could obviously prevent hepatocyte cytochrome P450, aminopyrine demethylase activity decreased and intrahepatic lipid peroxidation product malondialdehyde content increased; also make the mitochondrial and microsomal α-tocopherol content increased significantly, and liver receptor Loss index of serum glycocholic acid content decreased, the pathology of liver cell degeneration and necrosis also significantly reduced. The remission of liver cells to CBD exposure found that intracellular free calcium concentration was significantly increased, and a clear dose-dependent relationship.